Search for the pharmacophore in prazosin for Transport-P |
| |
| Authors: | Zunszain Patricia A Federico Cesare Sechi Mario Al-Damluji Saad Ganellin C Robin |
| |
| Institution: | Department of Chemistry, Christopher Ingold Laboratories, University College London, 20 Gordon Street, London WC1H 0AJ, UK. |
| |
| Abstract: | Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4-amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
