1-Deaza and 3-deazapurines in the reaction of microbiological transglycosylation |
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| Authors: | I A Mikhailopulo A I Zinchenko S B Bokut N V Dudchik V N Baraj E N Kalinichenko H Rosemeyer F Seela |
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| Institution: | (1) Institute of Bioorganic Chemistry and Institute of Microbiology, Byelorussian Academy of Sciences, 220600 Minsk, Byelorussia;(2) Laboratorium für Organische und Bioorganische Chemie, Universität Osnabrück, D-4500 Osnabrück, Germany |
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| Abstract: | Summary Substrate activity of 1- and 3-deazapurines in the reaction of microbiological ribo- 2-deoxyribosylation catalysed by purine nucleoside phosphorylase of viable cells ofE. coli BMT-1D/1A has been studied. Guanosine or 2 -deoxyguanosine were used as donors. 1-Deazapurines are good substrates in both reactions; 3-deazapurines are very effective intransdeoxyribosylation but not intransribosylation. Benzimidazole is an excellent substrate in both reactions indicating that N(1) and N(3) are not essential for transglycosylation. |
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