New Dibenzocyclooctadiene Lignans and Phenolics from Kadsura heteroclite with Anti-Inflammatory Activity |
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| Authors: | Le Thi Thuy Le Huyen Tram Dinh Thi Phuong Anh Nguyen Thi Thuy My Nguyen Van Thong Nguyen Tuan Anh Dao Huy Toan Tran Thu Ha Bui Van Thanh Nguyen Thi Ngoc Mai Nguyen Ngoc Linh Duc-Dat Le Tran Thu Huong Nguyen Van Bach |
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| Institution: | 1. School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, 100000 Vietnam;2. Intellectual Property Office of Vietnam, Hanoi, 100000 Vietnam;3. Institute of Ecology and Biological Resources (IEBR), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, 100000 Vietnam;4. College of Pharmacy, Thanh Do University, Kim Chung, Hoai Duc, Hanoi, 10000 Vietnam;5. Vietnam Military Medical University, Hanoi, 100000 Vietnam |
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| Abstract: | A chemical investigation of K. heteroclite led to isolation of two new dibenzocyclooctadienes ( 1 and 2 ) together with 14 known compounds ( 3 – 16 ) by using multiple chromatographic techniques. New compounds ( 1 and 2 ) were obtained and identified by spectroscopic methods (HR-ESI-MS, 1D and 2D NMR, and ECD) as well as by comparison of their experimental data with those reported in the literatures. All the isolates were evaluated for their ability to modulate TNF-α production in lipopolysaccharide (LPS) stimulated RAW264.7 cells. Among them, compound 5 displayed the most inhibition against tumor necrosis factor (TNF)-α production with IC50 value of 6.16±0.14 μM. Whereas, compounds ( 1 , 3 , and 6 ) showed the significant inhibition (IC50 values ranging from 9.41 to 14.54 μM), and compounds ( 2 , 4 , 9 , 10 , 13 , 15 , and 16 ) exhibited moderate inhibition (IC50 values ranging from 19.27 to 40.64 μM) toward TNF-α production, respectively. |
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| Keywords: | Kadsura heteroclite Schizandraceae dibenzocyclooctadiene anti-inflammatory TNF-α |
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