| Affiliation: | 1. College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350 P. R. China Both authors contributed equally to this work.;2. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100 P. R. China;3. College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350 P. R. China;4. College of Chemistry, Nankai University, Tianjin, 300071 P. R. China |
| Abstract: | Two new 1,10-seco-eudesmanolides ( 1 and 2 ) were isolated from the flowers of Inula japonica together with two eudesmanolide analogs ( 3 and 4 ) and two monoterpene derivatives ( 5 and 6 ). Their structures were established on the basis of detailed spectroscopic analyses and electronic circular dichroism data. All isolates were evaluated for their antiproliferative activities against human hepatocarcinoma HepG2 and SMMC-7721 cells. Japonipene B ( 3 ) exhibited the most potent effect with the IC50 values of 14.60±1.62 and 22.06±1.34 μM against HepG2 and SMMC-7721 cells, respectively. Furthermore, japonipene B ( 3 ) showed significant efficacies of arresting the cell cycle at the S/G2-M stages, inducing mitochondria-mediated apoptosis, and inhibiting cell migration in HepG2 cells. |
