Phytochemical Profiling by UPLC-ESI-QTOF-MS of Kalaharia uncinata (Schinz) Moldenke,Widely Used in Traditional Medicine in DR Congo |
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Authors: | Pathy Kibungu Kembelo Dr Emmy Tuenter Dr Wouter Vanhove Prof?Dr Honoré Belesi Katula Prof?Dr Patrick Van Damme Prof?Dr Luc Pieters |
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Institution: | 1. Department of Environmental Sciences, Kinshasa University (UNIKIN), Kinshasa XI, BP 127 Kinshasa, Democratic Republic of Congo;2. Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, BE-2610 Antwerp, Belgium;3. Laboratory of Tropical and Subtropical Agriculture and Ethnobotany, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium;4. Laboratory of Tropical and Subtropical Agriculture and Ethnobotany, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium
Faculty of Tropical AgriSciences, Czech University of Life Sciences, Prague, Kamycka 129, 165 00 Praha – Suchdol, Czech Republic |
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Abstract: | Kalaharia uncinata (Schinz) Moldenke, is a tropical erect bushy shrub or subshrub of the Lamiaceae family. It is an endemic plant species of Southern Africa, widely used in the pharmacopoeia against upper respiratory tract infections. A previously conducted ethnobotanical survey revealed that it is believed to contain bioactive substances. However, no relevant phytochemical information was available. This study aimed to perform a phytochemical characterization of K. uncinata and also to discuss the potential bioactivity of the identified phytochemical constituents based on documented data. Ultra-performance liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOF-MS) was used for profiling and identification of the main phytochemical constituents from leaf extracts (MeOH 90 %, DCM, AcOEt, BuOH, hexane and residue) of K.uncinata. Twenty-four constituents, representing mainly flavonoids (14), followed by phenylethanoid glycosides (7), phenolic acids (2), and an iridoid glycoside (1) were tentatively identified. Most of the identified compounds are documented to have antiviral and anti-inflammatory properties, which could possibly be the rationale behind the use of K. uncinata against upper respiratory tract infections. |
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Keywords: | Kalaharia uncinata Lamiaceae phytochemical profiling UPLC-ESI-QTOF-MS upper respiratory tract infections |
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