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Antifungal Activity of Cadinane-Type Sesquiterpenes from Eupatorium adenophorum against Wood-Decaying Fungi |
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| Authors: | Yang Liu Deyan Wang Shijun Hu Jianrong Wu Jianmei Luo Mingming Cao Xiaohui Yan |
| Institution: | 1. Key Laboratory of Forest Disaster Warning and Control in Yunnan Province, College of Biodiversity Conservation, Southwest Forestry University, Kunming, Yunnan, 650233 China
These authors contributed equally to this work.;2. College of Forestry, Southwest Forestry University, Kunming, Yunnan, 650233 China;3. Key Laboratory of Forest Disaster Warning and Control in Yunnan Province, College of Biodiversity Conservation, Southwest Forestry University, Kunming, Yunnan, 650233 China;4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China |
| Abstract: | The present study aimed to evaluate the antifungal activities of Eupatorium adenophorum against four strains of wood-decaying fungi, including Inonotus hispida, Inonotus obliquus, and Inonotus cuticularis. Bioguided isolation of the methanol extract of E. adenophorum by silica gel column chromatography and high-performance liquid chromatography afforded six cadinane-type sesquiterpenes. Their structures were identified by nuclear magnetic resonance and MS analyses. According to the antifungal results, the inhibition rate of the compound was between 59.85 % and 77.98 % at a concentration of 200 μg/mL. The EC50 values ranged from 74.5 to 187.4 μg/mL. |
| Keywords: | antifungal activity antifungal agents cadinane-type sesquiterpenes Eupatorium adenophorum wood-decaying fungi |