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Phenylethanoid Glycosides from Caryopteris aureoglandulosa and Their Biological Activities |
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| Authors: | Yi Chen Hong-Tao Xu Tong Tian Xiao-Hui Wei Gui-Xin Chou |
| Affiliation: | 1. The MOE Key Laboratory of Standardization of Chinese Medicines and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, 201203 China Yi Chen and Hong-Tao Xu contributed equally to this work.;2. The MOE Key Laboratory of Standardization of Chinese Medicines and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, 201203 China;3. The MOE Key Laboratory of Standardization of Chinese Medicines and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China |
| Abstract: | This study describes the isolation and identification of two novel phenylethanoid glycosides, aureoglanduloside A ( 1 ) and aureoglanduloside B ( 2 ), as well as a newly discovered diterpene glycoside, aureoglanduloside C ( 29 ). Additionally, 31 known compounds were isolated from the n-butyl alcohol (BuOH) soluble fraction of Caryopteris aureoglandulosa whole dried plants. Their structures were characterized using various spectroscopic techniques and high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, the neuroprotective effects of all phenylethanoid glycosides were evaluated. Specifically, compounds 2 and 10 – 12 exhibited the ability to promote the phagocytosis of myelin by microglia, and compounds 2 , 10 – 11 , and 24 showed the ability to promote the phagocytosis of myelin by astrocytes. |
| Keywords: | Caryopteris aureoglandulosa Chemical constituent Neuroprotective Microglia Astrocytes |