| Institution: | 1. Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
These authors contributed equally to this work.;2. Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China |
| Abstract: | Six new phloroglucinol derivatives, xanchryones I−N ( 1 – 6 ), were isolated from the leaves of Xanthostemon chrysanthus. Compounds 1 – 6 are unusual phloroglucinol-amino acid hybrids constructed through C2−N and O−C1′ bonds forming a peculiar oxazole ring. The structures and absolute configurations of compounds 1 – 6 were determined by MS, NMR, and single-crystal X-ray diffraction. Moreover, the anti-inflammatory and antibacterial activities of these compounds were evaluated. |
