Effect of Axial Ligand Length on Biological and Anticancer Properties of Axially Disubstituted Silicon Phthalocyanines |
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Authors: | H Yasemin Yenilmez Nazli Farajzadeh Nilgün Güler Ku?çulu Dilek Bahar Sadin Özdemir Gül?ah Tollu Mithat Güllü Zehra Altunta? Bay?r |
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Institution: | 1. Department of Chemistry, Istanbul Technical University, TR-34469 Istanbul, Turkey;2. Department of Chemistry Technology, Mustafa Ç?kr?kç?o?lu Vocational School, Kayseri University, TR-38280 Kayseri, Turkey;3. Genome & Stem Cell Center (GENKOK), Erciyes University, TR-38039 Kayseri, Turkey;4. Food Processing Programme, Technical Science Vocational School, Mersin University, TR-33343 Yenisehir Mersin, Turkey;5. Department of Laboratory and Veterinary Health, Technical Science Vocational School, Mersin University, TR-33343 Yenisehir Mersin, Turkey;6. Department of Biology, Faculty of Science, Erciyes University, TR-38039 Kayseri, Turkey |
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Abstract: | In this study, three new axially disubstituted silicon phthalocyanines ( SiPc1–3 ) and their quaternized phthalocyanine derivatives ( QSiPc1–3 ) were prepared and characterized. The biological properties (antioxidant, antimicrobial, antibiofilm, and microbial cell viability activities) of the water-soluble silicon phthalocyanines were examined, as well. A 1 % DMSO diluted with pure water was used as a solvent in biological activity studies. All the compounds exhibited high antioxidant activity. They displayed efficient antimicrobial and antimicrobial photodynamic therapeutic properties against various microorganisms, especially Gram (+) bacteria. Additionally, they demonstrated high antibiofilm activities against S. aureus and P. aeruginosa. In addition, 100 % bacterial reduction was obtained for all the studied phthalocyanines against E. coli viable cells. Besides, the DNA cleavage and binding features of compounds ( QSiPc1–3 ) were studied using pBR322 DNA and CT-DNA, respectively. Furthermore, the human topoisomerase I enzyme inhibition activities of compounds QSiPc1 – 3 were studied. Anticancer properties of the water-soluble compounds were investigated using cell proliferation MTT assay. They exhibited anticarcinogenic activity against the human colon cancer cell line (DLD-1). Compounds QSiPc1 and QSiPc3 displayed a high anticarcinogenic effect on the DLD-1 cell line. The obtained results indicated that all the studied compounds may be effective biological agents and anticancer drugs after further investigations. |
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Keywords: | silicon phthalocyanine antioxidant antibiofilm topoisomerase-I enzyme inhibition MTT assay |
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