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Hyposterolactone A,a 3α-Hydroxy Steroidal Lactone from the Deep-Sea-Derived Fungus Hypocrea sp. ZEN14 |
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| Authors: | Lin Xu Hua-Bin Ma Taizong Wu Li-Fang Liu Ming-Min Xie Man-Yi Hu Ying-Bao Gai Tian-Hua Zhong Xian-Wen Yang |
| Institution: | 1. Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China
Lin Xu and Hua-Bin Ma contributed equally to this work.;2. Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005 China Lin Xu and Hua-Bin Ma contributed equally to this work.;3. Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072 Australia;4. Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China |
| Abstract: | Chemical investigation of the deep-sea-derived fungus Hypocrea sp. ZEN14 afforded a new 3α-hydroxy steroidal lactone, hyposterolactone A ( 1 ) and 25 known secondary metabolites ( 2 – 26 ). The structure of the new compound was established by detailed spectroscopic analysis, electronic circular dichroism (ECD) calculation as well as a J-based configuration analysis. Compound 10 showed potent cytotoxicity against Huh7 and Jurkat cells with IC50 values of 1.4 μM and 6.7 μM, respectively. |
| Keywords: | deep-sea fungus Hypocrea steroids ECD calculation J-based configuration analysis |