Rapid small scale preparation of bacterial genomic DNA, suitable for cloning and hybridization analysis |
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| Authors: | J LEWINGTON S D GREENAWAY † B J SPILLANE |
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| Institution: | Department of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK |
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| Abstract: | The uptake of noxythiolin by a urinary isolate of Escherichia coli was examined initially at 37°C but the adsorption isotherm was complicated by the concomitant degradation of the compound. When drug adsorption was investigated at 4°C, to reduce the degradation rate of the compound, it was observed that noxythiolin was taken up by the urinary isolate in a linear fashion. The resulting adsorption patterns are discussed in relation to their possible classification. The implications of this uptake are considered with respect to the antimicrobial activity of noxythiolin. |
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