|
|||||
|
|
Hepatoprotective effects of melatonin against pronecrotic cellular events in streptozotocin-induced diabetic rats |
|
| Authors: | Ilijana Grigorov Desanka Bogojević Sofija Jovanović Anja Petrović Svetlana Ivanović-Matić Lidija Zolotarevski Goran Poznanović Vesna Martinović |
| Affiliation: | 1. Department of Molecular Biology, Institute for Biological Research “Sini?a Stankovi?”, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Republic of Serbia 2. Institute for Pathology and Forensic Medicine, Military Medical Academy, Belgrade, Serbia |
| Abstract: | Oxidative stress-mediated damage to liver tissue underlies the pathological alterations in liver morphology and function that are observed in diabetes. We examined the effects of the antioxidant action of melatonin against necrosis-inducing DNA damage in hepatocytes of streptozotocin (STZ)-induced diabetic rats. Daily administration of melatonin (0.2 mg/kg) was initiated 3 days before diabetes induction and maintained for 4 weeks. Melatonin-treated diabetic rats exhibited improved markers of liver injury (P?P?P? |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |