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Oxidative damage and alterations in antioxidant enzyme activities in the kidneys of rat exposed to trichloroacetic acid: protective role of date palm fruit |
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| Authors: | Amira El Arem Mouna Zekri Amira Thouri Emna Behija Saafi Fatma Ghrairi Amel Ayed Abdelfattah Zakhama Lotfi Achour |
| Affiliation: | 1. Research Unit “Genome, Immune Diagnosis and Recovery”, Higher Institute of Biotechnology of Monastir, University of Monastir, Avenue Tahar Hadded, BP 74, 5000, Monastir, Tunisia 2. Laboratory of Biochemistry, Faculty of Medicine Sousse, University of Monastir, Avenue Mohamed Karoui, 99/UR/08-45, 4002, Sousse, Tunisia 3. Service of Pathological Anatomy CHU F Bourguiba, Monastir, Tunisia |
| Abstract: | In this study, we investigated the antioxidant and protective properties of date fruit aqueous extract (DFAE) on trichloroacetic acid (TCA)-induced nephrotoxicity in rat. Oral administration of TCA as drinking water (0.5 and 2 g/L) daily for 2 months caused nephrotoxicity as evident by elevated levels of plasma creatinine, urea, and uric acid. Activity of antioxidant enzymes, catalase (CAT) and glutathione peroxidase (GPx), was decreased, whereas superoxide dismutase (SOD) activity and malondialdehyde (MDA) level were increased along with histopathological injuries. The oral administration of DFAE (4 mL/kg/day) to TCA-treated groups proved some significant correction by increasing the antioxidant activity of the CAT and GPx enzymes and normalizing the SOD activity and the MDA level (p? |
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