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Discovery of novel intracellular receptor modulating drugs |
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| Authors: | Todd K. Jones Charles Pathirana Mark E. Goldman Lawrence G. Hamann Luc J. Farmer Teodoro Ianiro Michael G. Johnson Steven L. Bender Dale E. Mais Robert B. Stein |
| Affiliation: | Ligand Pharmaceuticals, Inc., 9393 Towne Centre Drive, San Diego, CA 92121, U.S.A. |
| Abstract: | Utilizing the co-transfection assay as a guide to determining structure activity relationships, we have been pursuing the discovery of non-steroidal hPR modulators. Small molecule, non-steroidal lead structures have been identified. Optimization of these structures has yielded more potent hPR modulators. Improved cross-reactivity profiles with other intracellular receptors are a feature of these compounds owing to their non-steroidal nature. |
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