Synthesis and anti-inflammatory activity of some new 4,5-dihydro-1,5-diaryl-1H-pyrazole-3-substituted-heteroazole derivatives |
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Authors: | Dekhane Deepak V Pawar Shivaji S Gupta Sunil Shingare Murlidhar S Patil C R Thore Shivaji N |
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Affiliation: | Department of Chemistry, Vinyakrao Patil Mahavidyala Vaijapur, Aurangabad, MS 423701, India. |
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Abstract: | A series of 4,5-dihydro-1,5-diaryl-1H-pyrazole-3-substituted-heteroazoles were designed and synthesized in order to obtain new compounds with potential anti-inflammatory activity. The title compounds were screened for in vivo anti-inflammatory activity by using Carrageenan induced rat paw edema method. Diclofenac sodium was used as a standard drug for comparison. Out of the 30 compounds tested, compound 19a, 19b, 25a, 25b exhibited significant anti-inflammatory activity. Selected compounds were also screened for in vitro COX-2 inhibition assay and analgesic activity in the acetic acid induced writhing model. |
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Keywords: | Anti-inflammatory Analgesic NSAIDs Pyrazoline |
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