Prevention of cocaine-induced hyperactivity by a naloxone isomer with no opiate antagonist activity |
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Authors: | Nithiananda Chatterjie George J Alexander Jeri A Sechzer Kenneth W Lieberman |
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Institution: | (1) New York State Institute for Basic Research in Developmental Disabilities, 10314 Staten Island, New York;(2) Department of Psychology, Pace University, 10038 New York, New York;(3) Department of Psychiatry, University of Medicine and Dentistry of New Jersey, 07107 Newark, New Jersey |
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Abstract: | Dextro-naloxone (+)-naloxone], an isomer with almost no opiate antagonist activity and no effect on spontaneous locomotor activity,
can reduce cocaine-induced hyperactivity in mice. The classical opiate antagonist,levo-naloxone (−)-naloxone], is known to counteract the excitatory motor effects of amphetamine and cocaine, but it has been
tacitly assumed that this action oflevo-naloxone is dependent on its ability to antagonize endogenous opioids. Our finding that a naloxone isomer with little or
no opioid antagonist activity is also able to inhibit the cocaine effect on spontaneous motility, calls for a reconsideration
of this assumption. |
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Keywords: | Cocaine hyperactivity naloxone dextro-naloxone opiate antagonist |
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