Evolution of Receptors for Growth Hormone and Somatolactin in Fish and Land Vertebrates: Lessons from the Lungfish and Sturgeon Orthologues |
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Authors: | Shoji Fukamachi Axel Meyer |
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Institution: | (1) Lehrstuhl für Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, D-78457 Konstanz, Germany |
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Abstract: | Two cognate hormones, growth hormone (GH) and somatolactin (SL), control several important physiological processes in vertebrates.
Knowledge about GH and its receptor (GHR) has accumulated over the last decades. However, much less is known about SL and
its receptor (SLR). SL is found only in fish (including lungfish), suggesting that it was present in the common ancestor of
vertebrates, but was lost secondarily in the lineage leading to land vertebrates after the lungfish branched off. SLR was suggested to be a duplicated copy of GHR acquired only in teleosts via the fish-specific genome duplication (FSGD). This scenario (i.e., the existence of SL but not
SLR in the vertebrate ancestors) is intriguing but contested. In this study, we first evaluated the plausibility of this scenario
through synteny analyses and found that the loci for GHR and SLR are located in syntenic genomic positions, whereas the loci for GH and SL are not. Next, we cloned GHRs of lungfish and sturgeon, which possess SL but did not undergo the FSGD (i.e., they should not possess SLR). Their phylogenetic
positions in the GHR/SLR gene tree further support the fish-specific scenario for the GHR–SLR duplication. Interestingly, their sequences share greater
similarity with teleost SLRs and reptilian/amphibian GHRs than with the GHRs of mammals, birds, and teleosts. On the basis
of these results, we discuss the validity of the nomenclature of the teleost-specific copy of GHR as SLR and an ancestral
receptor(s) for SL before the evolution of SLR during the FSGD. |
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Keywords: | Somatolactin receptor (SLR) Growth hormone receptor (GHR) Lungfish Sturgeon Fish-specific genome duplication (FSGD) Synteny Sub-functionalization |
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