Nicotine consumption of several mouse strains using a two bottle choice paradigm |
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Authors: | Susanne Aschhoff Karl-Christian Schroff Dieter B Wildenauer Elmar Richter |
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Institution: | 1Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University Munich, Germany 2Department of Psychiatry, University of Bonn, Germany |
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Abstract: | The two bottle choice paradigm provides a convenient method for the rapid screening of preferences of nicotine and a variety of other substances in rodents. A non-expensive, home-made bottle system with low fluid loss due to leakage or evaporation is introduced. Using this system, we tested nicotine preference of the mouse strains NMRI, C3H/J, DBA/2, ST/bJ, C57BL/6 and a cross between male A/J and female NMRI. Our results show different nicotine preference of tested mice with high nicotine preference of C57BL/6, a lower preference of C3H/J, A/J×NMRI, DBA/2 and NMRI and the lowest of ST/bJ. |
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Keywords: | Two bottle choice paradigm inbred mouse nicotine preference drinking water consumption |
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