Bifidus factor. I. A variant of Lactobacillus bifidus requiring a special growth factor |
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| Authors: | GYORGY P NORRIS R F ROSE C S |
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| Affiliation: | 1. Division of Nephrology, Department of Medicine, Sydney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania;2. Department of Surgery, Sydney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania;3. Department of Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania;4. Department of Pathology, Sydney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania;1. University of Copenhagen, Institute of Veterinary Disease Biology, 1870, Frederiksberg, Denmark;2. Kopenhagen Consulting, Kopenhagen Fur, 8200, Skejby, Denmark;3. Bindslev Animal Hospital, 9881, Bindslev, Denmark;4. National Food Institute, Technical University of Denmark, 2860, Søborg, Denmark;1. Department of Medical Sciences, School of Medicine, Pharmacy and Prevention, University of Ferrara, via L. Ariosto 35, I-41121 Ferrara, Italy;2. Second Internal Medicine Unit, Azienda Ospedaliera-Universitaria ‘S. Anna’, Ferrara, Italy;3. Department of Morphology, Surgery and Experimental Medicine, School of Medicine, Pharmacy and Prevention, University of Ferrara, Ferrara, Italy;4. Azienda Sanitaria Locale, Ferrara, Italy;5. Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy;6. Second Department of Propaedeutic Internal Medicine, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece;1. Division of Internal Medicine, Medstar Georgetown University Hospital, Washington, DC, United States;2. Division of Pulmonary and Critical Care Medicine, Medstar Georgetown University Hospital, Washington, DC, United States;3. Department of Pathology, Medstar Georgetown University Hospital, Washington, DC, United States;1. Plano Orthopedic Sports Medicine and Spine Center, Plano, Texas, U.S.A.;2. Southern California Orthopedic Institute, Van Nuys, California, U.S.A. |
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| Abstract: | Human milk contains an essential growth factor for a variant of Lactobacillus bifidus. In contrast cow's milk exhibits only very low activity for this variant. The variant has been named L. bifidus var. Penn.The bifidus factor in human milk is not destroyed or altered in its activity by autoclaving. The ash is inactive.A large number of organic compounds, including microbiological growth factors, yeast extract, and vitamins not represented in the original medium, as well as carbohydrates and several vegetable extracts, have been tested for growth-promoting activity and have been found ineffective. Very slight activity was exhibited by liver compounds.Morphologically, L. bifidus var. Penn is identical with regular strains of L. bifidus. Serologically, it differs from the regular strains tested. It tends to mutate and then loses its requirements for human milk. Attempts to adapt a regular strain of L. bifidus to human milk were unsuccessful. L. bifidus var. Penn may become mucoid without loss of its dependence on human milk. For L. bifidus var. Penn maltose cannot replace lactose as source of carbohydrate. Except in its requirement for lactose and for the special growth factor, differences in the metabolic pattern of L. bifidus var. Penn from the regular bifid strains have not been found. |
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