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Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway |
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| Authors: | Yikui Tian Wenjuan Zhang Dachuan Xia Paul Modi Degang Liang Minxin Wei |
| Affiliation: | (1) Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, P. R. China;(2) Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, P. R. China;(3) Department of Cardiac Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK |
| Abstract: | BackgroundPostconditioning (PostC) inhibits myocardial apoptosis after ischemia-reperfusion (I/R) injury. The JAK2-STAT3 pathway has anti-apoptotic effects and plays an essential role in the late protection of preconditioning. Our aim was to investigate the anti-apoptotic effect of PostC after prolonged reperfusion and the role of the JAK2-STAT3 pathway in the anti-apoptotic effect of PostC. |
| Keywords: | Ischemia/reperfusion injury apoptosis postconditioning JAK2-STAT3 pathway Bcl-2 |
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