The bound leading the bound: target-derived receptors act as guidance cues |
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| Authors: | Crone Steven A Lee Kuo-Fen |
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| Affiliation: | The Salk Institute, La Jolla, CA 92037, USA. |
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| Abstract: | Developing axons are guided to their targets by chemoattractive and chemorepulsive ligands. Ledda et al., in this issue of Neuron, demonstrate that the target-derived receptor glial cell line-derived neurotrophic factor receptor alpha1 (GFRalpha1) can also act in trans as an axon guidance molecule for neurons. |
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