Membrane hemifusion: crossing a chasm in two leaps |
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| Authors: | Chernomordik Leonid V Kozlov Michael M |
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| Affiliation: | Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. chernoml@mail.nih.gov |
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| Abstract: | During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry. |
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