Study on the ophthalmic diseases in ICR mice and BALB/c mice. |
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| Authors: | Shin Ae Park Seong Mok Jeong Na Young Yi Min Su Kim Man Bok Jeong Jun Gyo Suh Yang Seok Oh Moo Ho Won Tchi Chou Nam Jae Hak Park Kang Moon Seo |
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| Institution: | Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Korea. |
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| Abstract: | In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. The experimental animals without clinical disorders were selected regardless of sex. The ophthalmic diseases were examined by using special ophthalmic instruments: direct ophthalmoscope, indirect ophthalmoscope, slit-lamp biomicroscope and focal illuminator. The most prevalent ocular variation within normal limits was hyaloid vessel remnant (ICR mice, 28.2%; BALB/c mice, 31.9%) and the incidence gradually decreased with age. The ocular diseases found in ICR mice were retinal degeneration (9.8%), corneal scar (4.2%), focal cataract (2.2%), anisocoria (1.2%), corneal ulcer (0.2%) and uveitis (0.2%). In BALB/c mice, corneal scar (9.2%), focal cataract (1.7%) and corneal ulcer (0.8%) were the ocular diseases found. |
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