Practical asymmetric synthetic route to 4,4,4-trifluoro-3-hydroxybutyrate: head-to-tail and head-to-head crystallizations through double and single hydrogen bonds of hetero- and homochiral 4,4,4-trifluoro-3-hydroxybutyrophenones期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Practical asymmetric synthetic route to 4,4,4-trifluoro-3-hydroxybutyrate: head-to-tail and head-to-head crystallizations through double and single hydrogen bonds of hetero- and homochiral 4,4,4-trifluoro-3-hydroxybutyrophenones

Authors:	Ishii Akihiro Kanai Masatomi Higashiyama Kimio Mikami Koichi

Affiliation:	Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo, Japan.

Abstract:	A practical asymmetric synthetic route to 4,4,4-trifluoro-3-hydroxybutyrophenone and the butyric acid phenyl ester is described using heterochiral crystallization through double hydrogen bonding assembly in head-to-tail fashion and sequential Baeyer-Villiger oxidation reaction by trifluoroperacetic acid.

Keywords:	4,4,4‐trifluoro‐3‐hydroxybutyrophenone 4,4,4‐trifluoro‐3‐hydroxybutyrate homochiral conglomerate heterochiral racemate
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