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Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines |
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| Authors: | Sadashiva M P Mallesha H Hitesh N A Rangappa K S |
| Institution: | aDepartment of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India bDepartment of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore 570 006, India |
| Abstract: | Cycloaddition of C-imidazolyl-N-phenylnitrones with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E. coli and B. subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against F. moniliforme, A. niger and C. acremonium by using nystatin as a positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared. |
| Keywords: | Antimicrobial properties Synthesis Nitrones Isoxazolidine derivatives Cycloaddition |
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