Possible role of H1 histone in the differentiation of mouse erythroleukemia cells |
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Authors: | R A Flickinger E Brooks P Choi M Morlock B Parker J Snider |
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Affiliation: | Department of Biological Sciences, State University of New York, Buffalo 14260. |
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Abstract: | Serum-starved mouse erythroleukemia cells, stationary phase cells or cells cultured in dibutyryl cAMP (1 mM) can be induced to differentiate by addition of 20% fetal calf serum plus cycloheximide. Culturing unstarved log phase cells in 20% fetal calf serum plus low levels of cycloheximide and histone H1 also causes a significant level of differentiation. These same concentrations of cycloheximide and H1 histone employed separately with 20% fetal calf serum do not induce differentiation. The role these procedures may have in causing an accumulation of histone H1 and cell differentiation is discussed. |
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