An efficient process for production and purification of hyaluronic acid from <Emphasis Type="Italic">Streptococcus </Emphasis><Emphasis Type="Italic">equi</Emphasis> subsp. <Emphasis Type="Italic">zooepidemicus</Emphasis>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. zooepidemicus

Authors:	Vidhya Rangaswamy Dharmendra Jain

Affiliation:	(1) Industrial Biotechnology Group, Reliance Life Sciences Pvt. Ltd., R-282, TTC area of MIDC, Thane-Belapur Road, Rabale, Navi Mumbai, 400 701, India

Abstract:	Growth of Streptococcus zooepidemicus in a 10 l bioreactor with 50 g sucrose/l and 10 g casein hydrolysate/l gave 5–6 g hyaluronic acid/l after 24–28 h. Purification of hyaluronic acid gave a recovery of 65% with the final material having an Mr of ∼4 × 10⁶ Da with less than 0.1% protein.

Keywords:	Fermentation Hyaluronic acid Purification Streptococcus zooepidemicus
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