A homogeneity test in overviews with group sequentially monitored clinical trials |
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Authors: | Li Z Li Y |
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Institution: | Department of Biometrics and Statistical Sciences, Procter and Gamble Company, Mason, Ohio 45040, USA. li.z@pg.com |
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Abstract: | It is known that using statistical stopping rules in clinical trials can create an artificial heterogeneity of treatment effects in overviews of related trials (Hughes, Freedman, and Pocock, 1992, Biometrics 48, 41-53). If the true treatment effect being tested is small, as is often the case, the homogeneity test by DerSimonian and Laird (1986, Controlled Clinical Trials 7, 177-188) violates the size of the test very severely. This paper provides a new homogeneity test, which preserves the size of the test more accurately. The operating characteristics of the new test are examined through simulations. |
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Keywords: | Alpha spending function Clinical trial Homogeneity test Interim analysis Meta-analysis |
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