Sorption of plasma components on the surface of particles of fluorocarbon emulsions stabilized by proxanol 268 |
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| Authors: | Sklifas A N Shekhtman D G Evdokimov V A Temnov A A Antashov A V Kaptsov V V Ponomarchuk V V Vorob'ev S I Kukushkin N I |
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| Affiliation: | Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. |
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| Abstract: | It was found in the experiments in vivo and in vitro that the contact of perfluorocarbon emulsion stabilized with proxanol 268 with blood plasma leads to the sorption of various plasma proteins on the surface of emulsion particles. The profile of the proteins sorbed is complex and includes proteins with molecular weights ranging from 14 to 94 kDa. Among proteins sorbed on the emulsion particles circulating in blood, IgG was identified. Incubation of the emulsion stabilized with proxanol 268 with human blood plasma in vitro was shown to result in the sorption of IgG and IgA the perfluorocarbon particles. The sorbtion of serum proteins and immune complexes circulating in blood on the surface of perfluorocarbon particles stabilized with proxanol 268 was revealed to activate the complement system. |
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