Cutting edge: CD83 regulates the development of cellular immunity |
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Authors: | Scholler Nathalie Hayden-Ledbetter Martha Dahlin Amber Hellström Ingegerd Hellström Karl Erik Ledbetter Jeffrey A |
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Institution: | Laboratories of. Tumor Immunology, and Immunobiology, Pacific Northwest Research Institute, Seattle, WA 98122, USA. nscholler@seagen.com |
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Abstract: | We recently found that human CD83, a marker of mature dendritic cells, is an adhesion receptor that binds to resting monocytes and a subset of activated CD8(+) T cells. We injected CD83-Ig into mice transplanted with the immunogenic P815 mastocytoma and showed that it significantly enhanced the rate of tumor growth and inhibited the development of cytotoxic T cells. In contrast, mice immunized with CD83-transfected K1735 cells, a poorly immunogenic melanoma, could prevent the outgrowth of wild-type K1735 cells. Studies performed in vitro with human PBL showed that coimmobilized CD83-Ig and anti-CD3 enhanced T cell proliferation and increased the proportion of CD8(+) T cells. CD83-transfected B-lymphoblastoid T51 cells stimulated T cell proliferation more effectively than untransfected T51 cells in MLR cultures and increased the generation of cytolytic T cells. We conclude that CD83 is a functionally important receptor that can regulate the development of cellular immunity by interacting with its ligand(s). |
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