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The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats |
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| Authors: | Enza Topo Andrea Soricelli Antimo D'Aniello Salvatore Ronsini Gemma D'Aniello |
| Institution: | 1. Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Napoli, Italy 2. Università di Napoli Parthenope e Fondazione IRCCS-SDN, Via Gianturco 113, 80143, Naples, Italy 3. Department of Obstetrics and Gynecology, and Reproductive Medicine (IVF Unit), Hospital 'S Luca', 84078, Vallo della Lucania, Italy |
| Abstract: | BackgroundD-aspartic acid is an amino acid present in neuroendocrine tissues of invertebrates and vertebrates, including rats and humans. Here we investigated the effect of this amino acid on the release of LH and testosterone in the serum of humans and rats. Furthermore, we investigated the role of D-aspartate in the synthesis of LH and testosterone in the pituitary and testes of rats, and the molecular mechanisms by which this amino acid triggers its action. |
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