Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection in Mice but Are Not Required for the Development of Acquired Gamma Interferon-Mediated Protective Immunity |
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| Authors: | Ali M. Harandi Bo Svennerholm Jan Holmgren Kristina Eriksson |
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| Affiliation: | Departments of Medical Microbiology and Immunology1. and Clinical Virology,2. Göteborg University, 413 46 Göteborg, Sweden |
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| Abstract: | Using a combination of gene-targeted mice and neutralizing antibodies, we showed that interleukin-12 (IL-12) and IL-18 are important in the innate control of genital herpes simplex virus type 2 infection but were not found to be critical, either singly or in combination, for the development of a protective gamma interferon-mediated immune response. |
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