利用基因共表达网络分析蛋白质的相互作用

基于Hom in的基因共表达网络的比较分析,发现人类基因共表达网络和蛋白质相互作用数据之间存在一定的相关性。采用基因本体论对这两个网络重叠区域进行基因分类后发现,这些编码的蛋白质主要集中在对刺激物的应答途径之中。通过对该途径中的蛋白质相互作用网络作图,获得了两个独立的功能模块。通过对模块中的基因分类和关键基因分析得出两者分别对应于内外源刺激物的应答功能。本研究对于利用不断丰富的核酸公共数据信息挖掘蛋白质相互作用的研究具有积极的促进作用。

Use gene coexpression network in analyzing the protein protein interations

Based on comparative analysis of Homin's gene coexpression network,there was certain relativity between human gene coexpression network and protein-protein interaction data.The overlap regions between them were classified by gene ontology and indicated that most proteins encoded by genes fall into the response pathway on stimulus.Furthermore,a protein-protein interaction network was developed in this pathway and two independence modules were obtained.Through analyze the key genes in the modules,we conclude ...