A twisted tRNA intermediate sets the threshold for decoding |
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| Authors: | Yarus Michael Valle Mikel Frank Joachim |
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| Affiliation: | Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA. yarus@stripe.colorado.edu |
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| Abstract: | Putting together consistent cryo-EM structure, transient kinetic and mutant tRNA suppressor data, it appears that a deformed or waggling aminoacyl-tRNA is the critical transitional structure examined by the ribosome during decoding at the A site. The unusual conformation may be required for effective proofreading of the codon-anticodon complex. |
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