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Deficiency in the nuclear long noncoding RNA Charme causes myogenic defects and heart remodeling in mice
Authors:Tiziana Santini  Fabio Desideri  Mariangela Morlando  Alessio Colantoni  Claudia Carrieri  Carmine Nicoletti  Antonio Musarò  Dònal O’ Carroll  Irene Bozzoni
Institution:1. Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy;2. Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy;3. MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK;4. DAHFMO‐Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy;5. Institute Pasteur Fondazione Cenci‐Bolognetti, Sapienza University of Rome, Rome, Italy;6. Institute of Molecular Biology and Pathology, CNR, Sapienza University of Rome, Rome, Italy
Abstract:
Keywords:CRISPR/Cas9  epigenetic control  heart development  lncRNAs  myogenesis
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