Anti‐cancer therapy: senescence is the new black |
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| Authors: | Rodrigo Leite de Oliveira Rene Bernards |
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| Affiliation: | Division of Molecular Carcinogenesis, Oncode Institute, Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands |
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| Abstract: | Cellular senescence is a natural safeguard against cancer. Pharmacologically, it can be induced by drugs that inhibit the CDK4/6 kinases such as palbociclib, but the exact mechanism has never been dissected. Recent research by Miettinen et al ( 2018 ) reveals that senescence induced by this class of drugs is mediated by proteasome hyper‐activation. |
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