Hip to the Game: YAP/TAZ is required for nonmelanoma skin cancers |
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| Authors: | Matilde M Miranda William E Lowry |
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| Affiliation: | 1. Molecular Biology Institute, UCLA, Los Angeles, CA, USA;2. Department of Molecular Cell and Developmental Biology, UCLA, Los Angeles, CA, USA;3. Eli and Edythe Broad Center for Regenerative Medicine, UCLA, Los Angeles, CA, USA;4. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA |
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| Abstract: | Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the two most common skin cancers found in humans. These cancers can acquire drug resistance and pose considerable medical burdens to clinics and patients if left untreated. Two recent studies show that active Hippo signaling plays a critical role in initiating BCC and SCC tumorigenesis, providing new opportunities to develop therapies against these skin malignancies. |
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