Fed-batch culture of yeast Saccharomyces cerevisiae with a DO-stat method by a fuzzy controller |
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Authors: | Fan-Chiang Yang Der-Wei Maa |
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Institution: | Department of Chemical Engineering, Tunghai University Taichung, Taiwan 40704, R.O.C, TW
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Abstract: | In this research a fuzzy controller was built to perform fed-batch cultures of Saccharomyces cerevisiae with a DO-stat method. The basic principle of fed-batch culture employing the DO-stat method is that a rapid increase of dissolved oxygen concentration due to a lack of substrate (the DO signal) is used as an indicator for substrate feeding. The proposed fuzzy controller can diagnose the state of fermentation and determine a proper feed rate of substrate for the culture of high density and high yield. The results indicate that cell concentration reached to 110?g/l and residual sugar kept below the level of 0.05?g/l. |
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