Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties |
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Authors: | Siskou Ioanna C Rekka Eleni A Kourounakis Angeliki P Chrysselis Michael C Tsiakitzis Kariofyllis Kourounakis Panos N |
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Institution: | Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece. |
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Abstract: | Six novel ibuprofen derivatives and related structures, incorporating a proline moiety and designed for neurodegenerative disorders, are studied. They possess anti-inflammatory properties and three of them inhibited lipoxygenase. One compound was found to inhibit cyclooxygenase (COX)-2 production in spleenocytes from arthritic rats. The HS-containing compounds are potent antioxidants and one of them protected against glutathione loss after cerebral ischemia/reperfusion. They demonstrated lipid-lowering ability and seem to acquire low gastrointestinal toxicity. Acetylcholinesterase inhibitory activity, found in two of these compounds, may be an asset to their actions. |
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