首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Cellular adhesion molecules as targets for bacterial infection
Authors:Hauck Christof R  Agerer Franziska  Muenzner Petra  Schmitter Tim
Institution:1. Department of BioMechanical Engineering, Delft University of Technology, Delft, The Netherlands;2. Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands;3. Department of Gynecology, Sint Lucas Andreas Ziekenhuis, Amsterdam, The Netherlands;1. École Pratique des Hautes Études (EPHE) & Paris Research University, Paris, France;2. UMR 5175, CEFE – CNRS – Université de Montpellier, Montpellier, France;3. Laboratoire d''Écologie des Hydrosystèmes Naturels et Anthropisés (UMR5023 CNRS), Université Lyon 1, 69622 Villeurbanne, France;1. Departamento de Hematología y Unidad de Trasplante de Células Progenitoras Hematopoyéticas, Hospital de Especialidades del Centro Médico Nacional “La Raza” IMSS, México City, México;2. Grupo Consulmed del Hospital de Especialidades del Centro Médico Nacional “La Raza” IMSS, México City, México;1. Division of Neuropsychopharmacology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tartu, Estonia;2. Institute of Chemistry, University of Tartu, Tartu, Estonia;1. Research Centre for Infectious Diseases (ZINF), University of Würzburg, Würzburg 97080, Germany;2. Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg 97080, Germany;3. National Centre for Biotechnology (CNB), Spanish Research Council (CSIC), Darwin 3, Madrid 28049, Spain;1. Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan;2. Department of Public Health, College of Medicine National Cheng Kung University, Tainan, Taiwan;3. Graduate Institute of Clinical Medical Sciences, Chang Gung University, Tao-Yuan, Taiwan;4. College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
Abstract:A large number of bacterial pathogens targets cell adhesion molecules to establish an intimate contact with host cells and tissues. Members of the integrin, cadherin and immunoglobulin-related cell adhesion molecule (IgCAM) families are frequently recognized by specific bacterial surface proteins. Binding can trigger bacterial internalization following cytoskeletal rearrangements that are initiated upon receptor clustering. Moreover, signals emanating from the occupied receptors can result in cellular responses such as gene expression events that influence the phenotype of the infected cell. This review will address recent advances in our understanding of bacterial engagement of cellular adhesion molecules by discussing the binding of integrins by Staphylococcus aureus as well as the exploitation of IgCAMs by pathogenic Neisseria species.
Keywords:Neisseria gonorrhoeae  Staphylococcus aureus  Bacterial invasion  Cell adhesion  Integrin  CEACAM
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号