Adenine induced granulocytosis in the rabbit.

Peripheral blood specimens from rabbits injected parenterally with physiological saline, adenine sulfate and guanine sulfate were examined for white blood cell count changes. A significant leukocytosis occurred within forty-eight hours only after adenine sulfate administration. A differential analysis revealed the increase was in the heterophil (pseudoeosinophil, amphophil) population. A mild lymphopenia was noted. There were no clear cut trends in the eosinophil, basophil and monocyte populations. No leukocyte morphological changes were found on peripheral blood smears.