Centrosome proteins form an insoluble perinuclear matrix during muscle cell differentiation |
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| Authors: | Vlastimil Srsen Xavier Fant Rebecca Heald Catherine Rabouille Andreas Merdes |
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| Affiliation: | (1) Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Edinburgh, EH9 3JR, UK;(2) Department of Molecular & Biology, CellUniversity of California Berkeley, 142 Life Sciences Addition # 3200, Berkeley, CA 94720-3200, USA;(3) Department of Cell Biology and Institute of Biomembranes, The Cell Microscopy Centre,University Medical Centre Utrecht, 3584CX Utrecht, The Netherlands;(4) Centre National de la Recherche Scientifique-Pierre Fabre, UMR 2587, 3 rue des Satellites, 31400 Toulouse, France |
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| Abstract: | Background Muscle fibres are formed by elongation and fusion of myoblasts into myotubes. During this differentiation process, the cytoskeleton is reorganized, and proteins of the centrosome re-localize to the surface of the nucleus. The exact timing of this event, and the underlying molecular mechanisms are still poorly understood. |
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