Effect of cultural inheritance of reproductive compensation on the incidence of a sex-linked lethal disease |
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Authors: | Shozo Yokoyama Alan R Empleton |
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Institution: | 1. Department of Psychiatry, Washington University School of Medicine and Jewish Hospital of St. Louis, 216 South Kingshighway, St. Louis, Missouri 63110, U.S.A.;2. Department of Biology, Washington University, St. Louis, Missouri 63130, U.S.A. |
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Abstract: | For a sex-linked recessive lethal disease, a model is constructed to study reproductive compensation for having at least one normal male with partial cultural inheritance. The equilibrium frequency of heterozygous females depends on the probability that a female offspring of the compensating parents will not compensate, α, the probability that a female offspring of the non-compensating parents will compensate, β, and the mutation rate, u. When α = 0, the equilibrium frequency of heterozygous females is given by √2u, whereas when α ≠ 0 it is given by 2{β +(2α + β) (α + β)}/{α(α + β)}]u.Then, the proportion of affected males due to fresh mutations is much smaller than Haldane's estimate of without reproductive compensation. |
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