Vincamine: A psychogeriatric agent blocking synaptic potentiation in hippocampus |
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Authors: | Hans-Rudolf Olpe German Barrioneuvo Gary Lynch |
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Institution: | 1. Ciba-Geigy Ltd. Pharmaceuticals Division 4002 Basel, Switzerland;2. Department of Psychobiology University of California Irvine, California 92717, USA |
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Abstract: | The action of vincamine on the physiology of the CAl region of the in vitro hippocampal slice preparation was investigated. At concentrations of 1, 10 and 100 μM, a five-minute perfusion with vincamine did not affect the synaptically-mediated activation of pyramidal neurons evoked by stimulation of the Schaffer-commissural fiber system. The effect of vincamine on the excitability of the pyramidal neurons was investigated by studying its effect on the antidromically-elicited field potential and the input-output relation of Schaffer-commissural fiber input. No effect on either of the two parameters was seen at a concentration of 100 μM of vincamine.Vincamine did, however, attenuate both the post-tetanic (PTP) and long-term potentiation (LTP) evoked by repetitive stimulation of the Schaffer-commissural fiber system. At a concentration of 100 μM of vincamine, PTP was significantly reduced and LTP was almost completely suppressed. |
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