Possible conformation of delta-lysin,a membrane-damaging peptide of Staphylococcus aureus |
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Authors: | J.H. Freer T.H. Birkbeck |
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Affiliation: | Department of Microbiology, University of Glasgow, Anderson College, 56 Dumbarton Road, Glasgow G11 6NU, Scotland |
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Abstract: | It is proposed that staphylococcal delta-lysin, a membrane-damaging peptide of 26 residues adopts an α-helical rod-like configuration with separate hydrophilic and hydrophobic faces. Association of six such monomers in a cell membrane may result in the formation of a transmembrane “pore” lined by the hydrophilic faces of the monomers. |
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