Corticotropin-releasing factor stimulates adenylate cyclase activity in the anterior pituitary gland |
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| Authors: | Fernand Labrie Bernard Gagné Gérard Lefèvre |
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| Institution: | Department of Molecular Endocrinology, Le Centre Hospitalier de l''Université Laval, Québec G1V 4G2, Canada |
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| Abstract: | Ovine corticotropin-releasing factor (CRF) stimulates adenylate cyclase activity in rat anterior pituitary homogenate at an ED50 value of 70 nM. GTP increases the stimulatory effect of CRF on 32P] cyclic AMP formation in a rat adenohypophysial particulate fraction and in bovine anterior pituitary plasma membranes. The present data show that CRF stimulates adenylate cyclase activity in the anterior pituitary gland at least partly through a guanyl nucleotide-dependent mechanism. |
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