The influence of indomethacin on collagen synthesis during tendon healing in the rabbit |
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| Authors: | C.A. Carlstedt K. Madsen T. Wredmark |
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| Affiliation: | 1. University of Aachen Medical Center, Department of Orthopaedic Trauma, Pauwelsstraße 30, 52074 Aachen, Germany;2. University of Aachen Medical Center, Department of Diagnostic and Interventional Radiology, Pauwelsstraße 30, 52074 Aachen, Germany;3. University of Zurich, Department of Trauma, Rämistrasse 100, 8091 Zürich, Switzerland;1. Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, 366-1, Ssangyoung-dong, Cheonan City, Chungnam 330-090, Republic of Korea;2. Department of Regenerative Medicine, Institute of Tissue Regeneration College of Medicine, Soonchunhyang University, 366-1, Ssangyoung-dong, Cheonan City, Chungnam 330-090, Republic of Korea;3. Department of Cardiovascular and Thoracic Surgery, Soonchunhyang University Hospital, 31, Soonchunhyang 6-gil, Dongnam-gu, Cheonan City, Chungcheongnam-do, Republic of Korea |
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| Abstract: | The influence of indomethacin on collagen synthesis in intact and healing plantaris longus tendons in the rabbit was investigated. Forty-four male New Zealand White rabbits were subjected to a standardized trauma (tenetomy + repair) on the left hindlimb. Half of the animals were subsequently treated with indomethacin, 10 mg/kg per day orally, and the other half with placebo. After 2 and 4 weeks the rabbits were injected intravenously with 3H-proline and killed 18 h later. Indomethacin affected the collagen metabolism differently depending on whether the tendons were involved in wound healing or not. In intact tendons the drug caused a small general inhibition of collagen synthesis. In the healing tendon there was a shift towards the synthesis of more insoluble collagen with little effect on the total synthesis. After 4 weeks there was also a slight but significant decrease in the amount of hydroxyproline in the most soluble collagen fraction from the tenotomized, indomethacin treated tendons. |
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