Isolation and sequence determination of cDNA encoding PMP-22 (PAS-II/SR13/Gas-3) of human peripheral myelin. |
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| Authors: | K Hayasaka M Himoro K Nanao W Sato M Miura K Uyemura E Takahashi G Takada |
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| Institution: | Department of Pediatrics and Dentistry, Akita University School of Medicine, Japan. |
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| Abstract: | A full length cDNA of PMP-22 (PAS-II/SR13/Gas-3) of peripheral myelin has been isolated from a cDNA library of human fetus spinal cord. The clone is 1823 base pairs (bp) in length and contains a 480 bp open reading frame encoding a polypeptide of 160 residues. The deduced amino acid sequence is highly homologous to PMP-22 from bovine (PAS-II), rat (SR13) and mouse (Gas-3). |
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