Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy |
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| Authors: | Wei S Lian Heng Lin Winston TK Cheng Tateki Kikuchi Ching F Cheng |
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| Affiliation: | (1) Department of Medical Research, Tzu Chi General Hospital and Department of Pediatrics, Tzu Chi University, Hualien, Taiwan;(2) Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan;(3) Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan;(4) Institute of Toxicology and Pharmacology, Tzu Chi University, Hualien, Taiwan;(5) Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan |
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| Abstract: | Background Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients developed re-stenosis and worsened condition post G-CSF delivery. This study presents a new disease model to study G-CSF induced cardiac thrombosis and delineate its possible mechanism. We used iron loading to mimic condition of chronic cardiac dysfunction and apply G-CSF to mice to test our hypothesis. |
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