Analysis of the differences in the folding mechanisms of c-type lysozymes based on contact maps constructed with interresidue average distances |
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| Authors: | Shunsuke Nakajima Takeshi Kikuchi |
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| Affiliation: | (1) Department of Chemistry and Bioscience, College of Industrial Technology, Kurashiki University of Science and the Arts, Kurashiki, Okayama, Japan;(2) Department of Bioscience and Bioinformatics, College of Information Science and Engineering, Ritsumeikan University, Nojihigashi, Kusatsu, Shiga 525–8577, Japan |
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| Abstract: | A method for analyzing differences in the folding mechanisms of proteins in the same family is presented. Using only information from the amino acid sequences, contact maps derived from the interresidue average distances are employed. These maps, referred to as average distance maps (ADM), are applied to the folding of c-type lysozymes. The results reveal that the ADMs of these lysozymes reflect the differences in the detailed folding mechanisms. Further possible applications of the present method are also discussed. |
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| Keywords: | Average distance map Folding mechanism Lysozyme family Prediction of folding from sequence |
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